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Downregulation of relapse-associated genes by short-hairpin inhibitory RNA sequences. (a) shRNA constructs targeting survivin, securin, TOP2A and cyclin B1 effectively reduce mRNA expression as determined by RT-PCR at 48 h after transfection. Results are expressed relative to transfection with scrambled shRNA (control)±s.d. (b) Determination of concordant changes in protein expression by western blot at indicated time points in Molt4 cells.
