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Downregulation of survivin results in increased caspase 3 activation and change in the cell-cycle profile. Western blot analysis of survivin, cleaved caspase 3 and actin expression following targeting of survivin mRNA with (a) shRNA in Molt4 cells or EZN-3042 in Reh cells and challenge with etoposide. (b) Propidium iodide staining and flow cytometric analysis of Molt4 cells 48h following transfection with survivin antisense EZN-3042 or scrambled control EZN-3046.
