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. Author manuscript; available in PMC: 2013 Nov 19.
Published in final edited form as: J Immunol. 2012 Oct 10;189(10):10.4049/jimmunol.1201622. doi: 10.4049/jimmunol.1201622

Figure 3.

Figure 3

Analysis of VH and VL gene usage and CDR sequence of 1E4. Panel A, analysis of 1E4 VH and VL gene usage by IMGT/V-QUEST. a: identity to germline genes. Panel B, comparison of amino acid sequence of 1E4 VH gene with the anti-Neisseria meningitidis group B polysaccharide mAb SEAM12 and murine germline family IGHV13-2 by ClustalW program. A star (*) indicates the same amino acid residue identity in a position, while a dot (:) indicates a different residue, and a dash (-) indicates inserted spaces placed in the sequence to provide maximum identity. Panel C, comparison of the HCDR3 conjunction between 1E4 and SEAM12. N: nucleotide addition mutation; P: P deletion mutation.