Table 1. A list of methylated genes in ALL.
Table 1 summarizes a partial list of genes reported to be methylated in ALL, as well as their chromosomal location, potential function (when known) and the number and percentage of metyhylation. It should be noted that a number of techniques were used to determine methylation and that criteria for “methylation positivity” may difer from study to study. This table is therefore only orientative.
| Gene | Chromosomal location | Function | Number methylated/Number analyzed | % (Range) | References |
|---|---|---|---|---|---|
| GIPC2 | 1p31 | Prostanoid signalling | 31/31 | 100 | 33 |
| RSPO1 | 1p34 | Wnt signalling | 46/46 | 100 | 33 |
| P73 | 1p36 | Transcription factor | 11/35, 17/80, 45/251 | 20 (18–31) | 19,20,30,32 |
| KCNK2 | 1q41 | K+ channel | 14/16 | 87 | 34 |
| LRP1B | 2q21 | LDL complex | 15/16 | 93 | 34 |
| DCL-1 | 2q24 | GTPase negative regulator | 11/16 | 68 | 34 |
| CAST1 | 3p14 | CNS, synapsis | 49/57 | 86 | 33 |
| MAGI1 | 3p14 | Guanylate kinase | 27/45 | 60 | 33 |
| WntA5 | 3p21 | Wnt signaling | 132/307 | 43 | 35 |
| ADCY5 | 3q13 | 38/56 | 68 | 33 | |
| CD10 | 3q25 | Peptidase | 8/80 | 10 | 30 |
| HSPA4L | 4q28 | Heat shock protein | 24/35 | 69 | 33 |
| sFRP2 | 4q31 | Wnt signaling | 42/261 | 16 | 35 |
| OCLN | 5q13 | Tight junction | 31/41 | 76 | 33 |
| EFNA5 | 5q21 | Ephrin signalling | 44/58 | 76 | 33 |
| MSX2 | 5q34 | Transcriptional repressor | 54/55 | 98 | 33 |
| GFPT2 | 5q34 | Aminotransferase | 8/35 | 23 | 33 |
| LATS1 | 6q24 | Kinase | 100/251 | 40 | 32 |
| ER | 6q25 | Estrogen receptor | 17/18, 29/80 | 47 (36–94) | 22, 30 |
| PARKIN | 6q25 | Proteosomal degradation | 67/251 | 27 | 32 |
| THSBS2 | 6q27 | Cell adhesion | 42/80 | 52 | 30 |
| sFRP4 | 7p14 | Wnt signaling | 55/261 | 21 | 35 |
| MDR1 | 7q21 | Transmembrane transporter | 36/80 | 45 | 30 |
| sFRP1 | 8p12 | Wnt signaling | 99/261 | 38 | 35 |
| P15 | 9p21 | Cell cycle control | 17/45, 20/46, 17/34, 19/80,73/251 | 32 (23–50) | 16–18, 30,32 |
| GNA14 | 9q21 | G protein | 27/44 | 59 | 33 |
| DBC1 | 9q32 | Inhibitor of Sirt1 | 29/170 | 17 | 26 |
| c-ABL | 9q34 | Kinase | 6/80 | 8 | 30 |
| DAPK | 9q34 | Apoptosis | 33 | 13 | 32 |
| PTEN | 10q23 | Phosphatase | 50 | 20 | 32 |
| sFRP5 | 10q24 | Wnt signaling | 73 | 28 | 35 |
| BNIP3 | 10q26 | Apoptosis | 5/34 | 15 | 27 |
| Calcitonin | 11p15 | Calcium metabolism | 6/7, 13/14, 44/47, 45/105 | 62 (42–93) | 12–15 |
| Dkk3 | 11p15 | Wnt signaling | 60/183 | 33 | 35 |
| P57 | 11p15 | Cell cycle control | 31/63, 45/251 | 30 (18–50) | 30,32 |
| SLC2A14 | 12p13 | Glucose transport | 12/16 | 75 | 34 |
| WIF1 | 12q14 | Wnt signaling | 78 | 30 | 35 |
| APAF-1 | 12q23 | Apoptosis | 85 | 34 | 32 |
| DDX51 | 12q24 | 8/16 | 50 | 34 | |
| HDPR1 | 14q23 | Wnt signaling | 68/261 | 26 | 35 |
| THSBS1 | 15q15 | Cell adhesion | 16/80 | 20 | 30 |
| NOPE | 15q22 | 13/16 | 81 | 34 | |
| SALL1 | 16q12 | Zn finger protein | 41/41 | 100 | 33 |
| E-cadherin | 16q22 | Cell adhesion | 18/33, 92/251 | 39 (37–54) | 21, 30 |
| CDH-13 | 16q24 | Cell adhesion | 87/251 | 35 | 32 |
| DCC | 18q21 | Putative tumor suppressor gene | 14/16 | 87 | 34 |
| MY05B | 18q21 | Protein traffick | 36/36 | 100 | 33 |
| ZNF382 | 19q13 | Zn finger protein | 24/46 | 52 | 33 |
| NES-1 | 19q13 | Serine protease | 143/251 | 57 | 32 |
| Hck | 20q11 | Kinase | 9/44 | 20 | 25 |
| TMS-1 | 20q13 | 22/251 | 9 | 32 | |
| MN1 | 22q12 | Involved in meningioma | 45/53 | 85 | 33 |