. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Dev Biol. 2013 Jun 17;381(1):10.1016/j.ydbio.2013.06.010. doi: 10.1016/j.ydbio.2013.06.010

Table 1.

Biological processes enriched among the genes upregulated more than 1.7 fold in FN-null embryos (n=8) compared with controls (n=7). P is the value of probability adjusted for multiple testing using the FDR (false discovery rate) correction. The last column lists genes in each GO category upregulated in FN-null mutants.

GO Category	Fold enrichment	P (FDR)	Genes
Myofibril	14	5.22E-11	ACTA1, MYL2, CRYAB, MYBPC3, LDB3, ACTN2, MYH7, MYH6, TNNI3, TTN, TRIM63, CSRP3, PGM5, ITGB1BP2, RYR2, SLC4A1, MYOM
Contractile fiber	13.6	1.06E-10	ACTA1, MYL2, CRYAB, MYBPC3, LDB3, ACTN2, MYH7, MYH6, TNNI3, TTN, TRIM63, CSRP3, PGM5, ITGB1BP2, RYR2, SLC4A1, MYOM1
Sarcomere	15	1.25E-10	ACTA1, CRYAB, MYBPC3, LDB3, ACTN2, MYH7, MYH6, TNNI3, TTN, TRIM63, CSRP3, PGM5, ITGB1BP2, RYR2, SLC4A1, MYOM1
Z disk	16.5	8.58E-06	PGM5, CRYAB, ITGB1BP2, LDB3, RYR2, ACTN2, SLC4A1, TTN, TRIM63, CSRP3
I band	14	3.19E-05	PGM5, CRYAB, ITGB1BP2, LDB3, RYR2, ACTN2, SLC4A1, TTN, TRIM63, CSRP3
Myosin complex	12	1.14E-04	MYL4, MYL2, DYNLL2, MYL3, MYBPC3, MYH7, MYH6, MYOM1, TTN, MYL9
Actin cytoskeleton	5.5	6.32E-04	MYL4, ACTA1, MYL2, MYL3, MYBPC3, ACTN2, MYH7, MYH6, TTN, MYL9, ANXA2, ARPC1B, ARPC3, DYNLL2, MYOM1
Hypertrophic cardiomyopathy	7	0.009	SLC8A1, MYL2, MYL3, MYBPC3, RYR2, MYH7, MYH6, TNNI3, TTN, CACNA2D2