Skip to main content
. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Front Neuroendocrinol. 2013 Jul 17;34(3):10.1016/j.yfrne.2013.07.003. doi: 10.1016/j.yfrne.2013.07.003

Fig. 11.

Fig. 11

Effects of KNDy neuron ablation on Serum LH (mean ± SEM, n = 6–8 rats/ group). On day 0, rats were ovariectomized (OVX) and injected with NK3-SAP (KNDy ablated) or Blank-SAP in the arcuate nucleus. From 20 to 23 days later and they were implanted s.c. with E2 capsules and sacrificed 11 days later. In Blank-SAP controls, serum LH was markedly increased after ovariectomy and reduced by E2 treatment. In KNDy-ablated rats, LH did not significantly rise three weeks after OVX. Serum LH was also lower in KNDy ablated rats, vs Blank-SAP controls after estrogen treatment. These data show that KNDy neurons are essential for the rise in LH secretion after ovariectomy and tonic LH secretion in estrogen-treated rats. # Significantly different, Blank-SAP vs. NK3-SAP. + Significantly different from intact values on day 0. * Significantly reduced after E2 treatment (compared to OVX). Modified with permission from Mittelman-Smith et al. (2012b).