Fig. 4.

Pattern of pulsatile LH release and associated flush episodes in four postmenopausal women. The arrows indicate flush onset. Each graph illustrates a separate 8- to 10-h study in which blood samples were obtained at 15-min intervals. The close timing of LH pulses and hot flushes provides evidence that the mechanism of flushes is linked with the hypothalamic control of pulsatile GnRH secretion. Reproduced with permission from Casper et al. (1979).