Table 2. Patient Characteristics at Study Entry.
| ALL patients (N=517) | COG studies (N=281) | CALGB studies (N=149) | SWOG studies (N=87) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | p-value | ||
| Studies | ||||||||||
| CCG-2861 | 13 | 3% | 13 | 5% | ||||||
| CCG-2891 STD | 29 | 6% | 29 | 10% | ||||||
| CCG-2891 INT | 56 | 11% | 56 | 20% | ||||||
| CCG-2941 | 6 | 1% | 6 | 2% | ||||||
| CCG-2961 | 123 | 24% | 123 | 44% | ||||||
| AAML03P1 | 54 | 10% | 54 | 19% | ||||||
| CALGB 8525 | 44 | 9% | 44 | 30% | ||||||
| CALGB 9022 | 19 | 4% | 19 | 13% | ||||||
| CALGB 9222 | 30 | 6% | 30 | 20% | ||||||
| CALGB 9621 | 17 | 3% | 17 | 11% | ||||||
| CALGB 19808 | 39 | 8% | 39 | 26% | ||||||
| SWOG S8600 | 51 | 10% | 51 | 59% | ||||||
| SWOG S9500 | 8 | 2% | 8 | 9% | ||||||
| SWOG S0106 | 28 | 5% | 28 | 32% | ||||||
| Gender | ||||||||||
| Male | 275 | 53% | 156 | 56% | 70 | 47% | 49 | 56% | 0.196 | |
| Female | 242 | 47% | 125 | 44% | 79 | 53% | 38 | 44% | ||
| Age (yrs) | ||||||||||
| 16 | 128 | 25% | 124 | 44% | 3 | 2% | 1 | 1% | ||
| 17 | 132 | 26% | 111 | 40% | 14 | 9% | 7 | 8% | ||
| 18 | 81 | 16% | 28 | 10% | 34 | 23% | 19 | 22% | ||
| 19 | 51 | 10% | 12 | 4% | 21 | 14% | 18 | 21% | ||
| 20 | 64 | 12% | 5 | 2% | 38 | 26% | 20 | 23% | ||
| 21 | 61 | 12% | 1 | 0% | 39 | 26% | 22 | 25% | ||
| Median | Range | Median | Range | Median | Range | Median | Range | p-value | ||
| Age - median (range) | 18.0 | (16.0 - 21.99) | 17.2 | (16.0 - 21.6) | 20.1 | (16.5 - 21.98) | 19.8 | (16.9 - 21.99) | <0.001 | |
| WBC (×103/μL) - median (range) | 19.1 | (0.5 - 860) | 20 | (0.5 - 860) | 18.1 | (0.5 - 453) | 16.8 | (0.6 - 415.8) | 0.669 | |
| BM Blasts % - median (range) | 73 | (0 - 100) | 74 | (1 - 100) | 71.5 | (0 - 99) | 70.5 | (0 - 100) | 0.570 | |
| FAB Classification | ||||||||||
| M0 | 17 | 3% | 12 | 4% | 4 | 3% | 1 | 1% | 0.348 | |
| M1 | 96 | 19% | 54 | 19% | 23 | 16% | 19 | 23% | 0.413 | |
| M2 | 179 | 35% | 94 | 34% | 57 | 39% | 28 | 34% | 0.490 | |
| M4 | 137 | 27% | 73 | 26% | 40 | 28% | 24 | 29% | 0.870 | |
| M5 | 49 | 10% | 28 | 10% | 12 | 8% | 9 | 11% | 0.780 | |
| M6 | 11 | 2% | 5 | 2% | 4 | 3% | 2 | 2% | 0.806 | |
| M7 | 5 | 1% | 4 | 1% | 1 | 1% | 0 | 0% | 0.462 | |
| Other | 13 | 3% | 9 | 3% | 4 | 3% | 0 | 0% | ||
| Unknown | 10 | 2 | 4 | 4 | ||||||
| Weight group (Body Mass Index) | ||||||||||
| Underweight (BMI ≤ 11%) | 52 | 10% | 24 | 9% | 20 | 13% | 8 | 9% | 0.103 | |
| Middleweight (BMI 11 - 94%) | 346 | 67% | 201 | 72% | 90 | 60% | 55 | 63% | 0.806 | |
| Obese (BMI ≥ 95%) | 117 | 23% | 54 | 19% | 39 | 26% | 24 | 28% | 0.233 | |
| Unknown | 2 | 2 | 0 | 0 | ||||||