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. 2013 Nov 19;8(11):e80316. doi: 10.1371/journal.pone.0080316

Table 7. Health disorders in early-lactation dairy cows during the experimental period.

Treatments1
Item2 Control 1.5 µg/kg 3.0 µg/kg Total
Ketosis 1 3 3 7
Subclinical mastitis 1 0 2 3
Respiratory distress 0 0 2 2
Metritis 1 0 0 1
Milk fever 0 0 1 1
Fever 0 0 2 2
≥1 event (fever excluded) 2 3 7 12
1

Treatments: cows were given 0, 1.5, or 3.0 µg/kg body weight rbTNFα injections daily for the first 7 days of lactation, respectively. There were 11 cows at risk in each treatment.

2

Ketosis was recorded when the urine ketone dipstick test (Ketostix; Bayer Corp. Diagnostics Division, Elkhart, IN) detected acetoacetate>80 mg/dL on any day or>40 mg/dL for 2 consecutive days. Fever designates that a cow had a rectal temperature greater than 39.4°C. Other health disorders were diagnosed according to the guidelines by Kelton et al. [14]. Fever was excluded from the summary data because of the possibility that it was a direct response to treatment rather than a sign of infection.