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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Neurochem. 2013 Jul 19;127(6):10.1111/jnc.12346. doi: 10.1111/jnc.12346

Figure 3. Genetic determination of traits by variation at the delta-sarcoglycan (SGCD) locus: Effects upon norepinephrine (NE) secretion as well as other physical, physiological, and biochemical traits.

Figure 3

Figure 3

Figure 3

Figure 3

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Figure 3

Figure 3

Results are shown as mean ± SEM. Significant differences (P<0.05) are bold.

(a) Peak effect in the SGCD local region on chromosome 5q33. Local region of the Manhattan plot displayed by SNAP (SNP Annotation and Proxy Search) plot <http://www.broadinstitute.org/mpg/snap/ldplot.php>. The peak associated with NE secretion is at SGCD (intron-4, rs1835919, in long clone uc0031wa.1).

(b) Coordinate effects on plasma and urine NE (uNE indicates urine norepinephrine; uUA urine uric acid, pUA, plasma uric acid; associated allele frequency and Hardy-Weinberg equilibrium (HWE) test results displayed);

(c) Inverse effects on plasma NE (pNE) and systemic vascular compliance (SVC);

(d) Coordinate effects on pNE and plasma free fatty acids (pFFA) secretion;

(e) Inverse effects on pNE and body mass index (BMI);

(f) Inverse effects on plasma and urine/plasma uric acid (UA) ratio;

(g) Coordinate effects on release of NE and chromogranin B (CHGB [439-451]) into the circulation.