Table 1.
Overview of the mitochondrial model parameters tested in the multiparametric sensitivity analysis of the Wu et al. (46) model of oxidative ATP metabolism in muscle
| Parameter No. | Model Parameter | Description |
|---|---|---|
| 1 | R | Dehydrogenase parameter |
| 2 | kPi,1 | Dehydrogenase parameter |
| 3 | kPi,2 | Dehydrogenase parameter |
| 4 | XDH | Dehydrogenase parameter |
| 5 | XC1 | Complex I activity |
| 6 | XC3 | Complex III activity |
| 7 | kPi,3 | Complex III parameter |
| 8 | kPi,4 | Complex III parameter |
| 9 | XC4 | Complex IV activity |
| 10 | kO2 | Complex IV parameter |
| 11 | XF1 | F0F1-ATPase activity |
| 12 | XANT | ANT activity |
| 13 | Km,ADP | Michaelis constant ANT |
| 14 | θ | ANT parameter |
| 15 | kPiHt | H+/Pi− cotransporter parameter |
| 16 | XPiHt | H+/Pi− cotransport activity |
| 17 | XKH | K+/H+ antiporter activity |
| 18 | XHle | H+ leak activity |
| 19 | β | Mitochondrial matrix buffering capacity |
ANT, adenine nucleotide translocator.