Fig. 4.

Effect of the histamine H2 receptor antagonist cimetidine on cysteamine-induced duodenal ulcers. A: cimetidine inhibited cysteamine-induced duodenal ulcers. The rats were pretreated with cimetidine 3 and 0.5 h before cysteamine and euthanized 3 h or 48 h after the first cysteamine dose. B: cimetidine decreased serum iron concentration alone or with cysteamine- vs. only saline-treated animals (3 h after cysteamine administration). C: cimetidine given to rats before cysteamine decreased iron concentration in the proximal duodenum vs. saline- or cysteamine-treated rats (3 h after cysteamine administration). Results are expressed as means ± SE (*P < 0.01, n = 5 for each group).