Figure 5. Erk2 regulates RhoA phosphorylation.

A. MLE12 cells were transfected with Erk2-V5 plasmid for 48 h. Cell lysates were subjected to immunoprecipitation with a RhoA antibody. The precipitates were probed with phospho-serine, phospho-threonine, and RhoA antibodies. Input cell lysates were subjected to V5 tag and β-actin immunoblotting. B. MLE12 cells were transfected with shCont or shErk2 plasmid for 72 h. Cell lysates were subjected to immunoprecipitation with a RhoA antibody. The precipitates were probed with phospho-serine and RhoA antibodies. Input cell lysates were subjected to Erk2 and β-actin immunoblotting. Shown are representative blots from three independent experiments.