Table 3.
Genetic association analysis for drug-induced liver injury (DILI) in 56 PAH patients treated with bosentan.
| Odds ratio1 | OR 95% CI lower limit | OR 95% CI upper limit | P | |
|---|---|---|---|---|
| Age | 0.94 | 0.86 | 1.04 | 0.24 |
| Sex | 1.21 | 0.09 | 68.2 | 1.00 |
| BMI | 0.96 | 0.83 | 1.11 | 0.62 |
| Hx liver disease | 0.00 | 0.00 | 18.2 | 1.00 |
| Bosentan exposure | 0.99 | 0.99 | 1.00 | 0.39 |
| Co-medications | 0.58 | 0.04 | 8.61 | 0.62 |
| ABCC2 | ||||
| rs717620 | 1.59 | 0.11 | 23.5 | 0.64 |
| rs2273697 | 0.46 | 0.01 | 6.18 | 0.64 |
| rs1885301 | 1.86 | 0.14 | 103 | 1.00 |
| rs7910642 | 0.00 | 0.00 | 8.41 | 1.00 |
| rs2804402 | 0.28 | 0.02 | 4.21 | 0.23 |
| ABCB11 | ||||
| rs2287622 | 0.45 | 0.03 | 6.74 | 0.59 |
| SLCO1B1 | ||||
| rs11045819 | 4.60 | 0.30 | 71.5 | 0.17 |
| rs2306283 | 2.01 | 0.15 | 112 | 1.00 |
| rs4149056 | 0.54 | 0.01 | 7.26 | 1.00 |
| SLCO1B3 | ||||
| rs7311358 | 0.83 | 0.02 | 11.2 | 1.00 |
| CYP2C9 | ||||
| *2/ rs1799853 | ∞ | 2.29 | ∞ | 0.003 |
| *3/ rs1057910 | 0.00 | 0.00 | 8.41 | 1.00 |
1
Odds ratio was calculated by logistic regression for continuous variables and by a Fisher exact test for dichotomous variables.