Figure 2.

Salivary PYY binds to Y₂Rs in the tongue epithelia. A, D, Representative images of a sagittal section of the murine tongue subjected to ¹²⁵I-PYY binding applied orally in vivo. B, E, Images of the tongue from a mouse in which ¹²⁵I-PYY was coadministered with the Y₂R-specific antagonist BIIE0246. C, F, Images of the tongue from a mouse in which ¹²⁵I-PYY was injected intraperitoneally. D–F, Micrographs of histological sections of the tongue epithelium with H&E staining; silver granules (black dots) colocalize with ¹²⁵I-PYY.