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. 2013 Nov 20;33(47):18425–18437. doi: 10.1523/JNEUROSCI.2775-13.2013

Figure 2.

Figure 2.

Effects of age and Aβ deposition on brain activity for successfully encoded (HC-HIT) versus forgotten items (MISS). a, Age-related differences in brain activity for successfully encoded versus forgotten items. Suprathreshold regions are overlaid on the inflated cortical surface in MNI space. The color scale represents t values with warm colors indicating significantly increased activity in young subjects compared with PIB−OLD for successfully encoded items compared with forgotten items. b, Aβ deposition shows greater brain activity for HC-HIT than MISS conditions. Suprathreshold regions are overlaid on the inflated cortical surface in MNI space. The color scale represents t values with warm colors indicating significantly increased activity in PIB+ OLD compared with PIB− OLD for successfully encoded items compared with forgotten items. No region shows significantly increased activity in PIB− OLD compared with PIB+ OLD adults in the same contrast. Maps show suprathreshold regions significant at p < 0.05 voxel level, with FDR correction at p < 0.05 at cluster level for multiple comparisons across the whole-brain volume. L, left hemisphere; R, right hemisphere.