Fig. 10.

Memantine and ketamine’s effects on LTP and LTD induction. (A) LTP induction [100 Hz for 1 second, arrow, high-frequency stimulus (HFS)] was unaffected by 10 µM memantine or ketamine (preapplied for 15 minutes as indicated). (B) LTD induction (1 Hz for 15 minutes white bar) was blocked by both drugs (10 µM, preapplied for 15 minutes). Drugs were administered for the durations shown by the black bars. LTP and LTD in control slices are shown by black circles (A) and white triangles (B). Six slices were tested for each experimental condition in A and B. Insets show representative fEPSP waveforms.