. 2013 Sep 29;47(3):456–466. doi: 10.1007/s11262-013-0980-5

Table 1.

Comparison of the number of amino acid changes in the HA1 with NA genes of the Sendai A(H1N1)pdm09 viruses during 2009–2011

Season	Hemagglutinin (HAl)		Neuraminidase (NA)
Season	Number of isolates	Mutation^a position^b (total)	Number of isolates	Mutation^a position^c (total)
Sep2009–Apr2010	43	V19l(1)	43	A75V(3)^S
		K22R(5)		A133L(1)
		V108L(1)		L140l(2)
		K171R(5)		V166F(1)
		A197T(25)		M242l(l)
		N228D(1)^GR		C292S(4)
		D274N(2)		G382E(4)^B
		T310K(4)		D416N(17)
		I333F(1)
Sep2010–Apr2011	32	K119N(1)^G	32	N44S(21)*^S
		A134T(11)^**R		I46T(10)**^S
		A141S(11)^**T		N50H(1)^S
		S143G(17)^*T		N68S(1)^S
		S183P(11)^**R		R152S(1)
		S185T(21)^*BR		E228D(1)
		L191l(1)^R		F231L(1)
		A197T(21)		V241l(21)*^T
		E213D(2)		R257K(1)
		Y230H(4)^**G		Q313R(11)^**
		V234l(1)		I321N(1)
		N260D/H(2)		N325K(1)
		I295V(11)^**		N369K(20)^*B
				P377R(1)
				V394l(11)**
				D392S(1)^B
				L415M(3)
				F445L(1)
Both	75	P83S(75)	75	1106V
		S203T(75)^T		N248D
		I321V(75)

Mutations found only in Sendai strains are written in bold

* Signature mutations of cluster I of the 2010–2011 season, ** Signature mutations of cluster II of the 2010–2011 season

^aAmmo acid changes are described using the sequence of A/California/07/09 as a reference

^bIn these columns, “B” indicates that the site is locatedin the B-cell antigenic region. “T” indicates that the site is located in the T-cell antigenic region. “R” denotes a receptor-binding site. “G” denotes a potential glycosylation site. H1 start numbering from the amino acids DTLC, counted as 1, used elsewhere in this study

^cIn these columns, “S” indicates that the site is located in the stalk region, and the rest of the sites are located in the head region of the NA gene. B indicates that the site is located in the B-cell antigenic region. T indicates that the site is located in the T-cell antigenic region