Table 1.
Season | Hemagglutinin (HAl) | Neuraminidase (NA) | ||
---|---|---|---|---|
Number of isolates | Mutationa positionb (total) | Number of isolates | Mutationa positionc (total) | |
Sep2009–Apr2010 | 43 | V19l(1) | 43 | A75V(3)S |
K22R(5) | A133L(1) | |||
V108L(1) | L140l(2) | |||
K171R(5) | V166F(1) | |||
A197T(25) | M242l(l) | |||
N228D(1)GR | C292S(4) | |||
D274N(2) | G382E(4)B | |||
T310K(4) | D416N(17) | |||
I333F(1) | ||||
Sep2010–Apr2011 | 32 | K119N(1)G | 32 | N44S(21)*S |
A134T(11)**R | I46T(10)**S | |||
A141S(11)**T | N50H(1)S | |||
S143G(17)*T | N68S(1)S | |||
S183P(11)**R | R152S(1) | |||
S185T(21)*BR | E228D(1) | |||
L191l(1)R | F231L(1) | |||
A197T(21) | V241l(21)*T | |||
E213D(2) | R257K(1) | |||
Y230H(4)**G | Q313R(11)** | |||
V234l(1) | I321N(1) | |||
N260D/H(2) | N325K(1) | |||
I295V(11)** | N369K(20)*B | |||
P377R(1) | ||||
V394l(11)** | ||||
D392S(1)B | ||||
L415M(3) | ||||
F445L(1) | ||||
Both | 75 | P83S(75) | 75 | 1106V |
S203T(75)T | N248D | |||
I321V(75) |
Mutations found only in Sendai strains are written in bold
* Signature mutations of cluster I of the 2010–2011 season, ** Signature mutations of cluster II of the 2010–2011 season
aAmmo acid changes are described using the sequence of A/California/07/09 as a reference
bIn these columns, “B” indicates that the site is locatedin the B-cell antigenic region. “T” indicates that the site is located in the T-cell antigenic region. “R” denotes a receptor-binding site. “G” denotes a potential glycosylation site. H1 start numbering from the amino acids DTLC, counted as 1, used elsewhere in this study
cIn these columns, “S” indicates that the site is located in the stalk region, and the rest of the sites are located in the head region of the NA gene. B indicates that the site is located in the B-cell antigenic region. T indicates that the site is located in the T-cell antigenic region