Table 1.
Demographic and clinical characteristics of the study sample according to diagnosis in 150 eyes of 99 subjects enrolled to compare the performance of the retinal nerve fiber and ganglion cell/inner plexiform layer measurements with spectral domain optical coherence tomography for detection of early glaucoma.
| Variables | Normal subjects | Glaucoma patients | P value |
|---|---|---|---|
| Number of eyes (patients) | 91 (52) | 59 (47) | |
| Age (mean ± SD, years) | 58.6 (±9.2) | 66.1 (±6.0) | <0.001a |
| Gender (female/male) | 58/33 | 36/23 | 0.737b |
| Race | |||
| White | 39 (75.0%) | 36 (76.6%) | |
| African-American | 4 (7.7%) | 6 (12.8%) | 0.620b |
| Hispanic | 3 (5.8%) | 2 (4.3%) | |
| Asian | 6 (11.5%) | 3 (6.4%) | |
| LogMAR visual acuity (mean ± SD) | 0.0 (±0.1) | 0.1 (±0.1) | 0.061a |
| Refractive error (Diopters, mean ± SD) | −0.4 (±2.4) | −1.2 (±2.6) | 0.154a |
| IOP (mmHg, mean ± SD) | 14.7 (±2.9) | 14.1 (±3.8) | 0.314a |
| Central corneal thickness (μm, mean ± SD) | 556.1 (±38.9) | 548.8 (±35.5) | 0.323a |
| Keratometry (Diopters, mean ± SD) | 44.2 (±1.5) | 43.9 (±1.4) | 0.260a |
| Lens status | |||
| Phakic | 91 (100%) | 42 (71.2%) | <0.001b |
| Pseudophakic | 0 (0%) | 17 (28.8%) | |
| Axial length (mm, mean ± SD) | 23.8 (±1.1) | 24.7 (±1.2) | <0.001a |
| Signal Strength Macular Cube (mean ± SD) | 8.7 (±1.0) | 8.3 (±0.8) | 0.010c |
| Signal Strength Optic Disc Cube (mean ± SD) | 8.8 (±1.0) | 8.0 (±0.8) | <0.001c |
| Disc area (mm2, mean ± SD) | 1.73 (±0.3) | 1.73 (±0.4) | 0.922a |
| Mean deviation (dB, mean ± SD) | −0.1 (±1.2) | −2.5 (±1.9) | <0.001c |
| Pattern standard deviation (dB, mean ± SD) | 1.6 (±0.4) | 4.5 (±2.2) | <0.001c |
a
Two-sample t test
b
Chi2 test
c
Wilcoxon's rank-sum test; SD: standard deviation; LogMAR: logarithm of minimum angle of resolution; IOP: intraocular pressure.