Table 2.
Mean Score and Impairment Frequency Pre-AuHSCT on Each Neuropsychological Test Grouped by Principal Cognitive Domain (N = 53)
| Cognitive Domain | Test | Abbreviation | RCI Study | Mean (SDa) | Impairedb (%) |
|---|---|---|---|---|---|
|
| |||||
| Attention | WAIS-III Digit Span | WAIS-III DSpan33 | Wechsler, 198133 | ||
| WAIS-III Digit Span forward | 0.45 (0.98) | 1.9 | |||
| WAIS-III Digit Span backward | 0.35 (0.99) | 0.0 | |||
|
| |||||
| Psychomotor speed | WAIS-III Digit Symbol | WAIS-III Symbol33 | Wechsler, 198133 | 0.34 (0.92) | 1.9 |
| Trail Making Test Part A | TMT-A34 | Levine, 200435 | 0.38 (1.29) | 11.3 | |
|
| |||||
| Learning/ memory | HVLT-R Total Recall | HVLT-R36 | Benedict, 199817 | −0.45 (1.12) | 18.9 |
| HVLT-R Delayed Recall | −0.36 (1.43) | 16.9 | |||
| HVLT-R Delayed Recognition | −0.29 (1.16) | 11.3 | |||
|
| |||||
| Executive function | Trail Making Test Part B | TMT-B34 | Levine, 200435 | −0.71 (3.39) | 28.3 |
| MAE Controlled Oral Word Association | COWA37 | Ruff, 199619 | −0.51 (1.15) | 20.8 | |
|
| |||||
| Motor | GPB-D (dominant hand) | GPB-D38 | Dikmen, 1999 | −0.61 (0.80) | 1.9 |
| GPB-ND (nondominant hand) | GPB-ND38 | −0.75 (0.65) | 0.0 | ||
Abbreviations: AuHSCT, autologous hematopoietic stem cell transplant; RCI, Reliable Change Index; SD, standard deviation from the mean; WAIS-III, Wechsler Adult Intelligence Scale-Third Edition; HVLT-R, Hopkins Verbal Learning Test-Revised; MAE, Multilingual Aphasia Examination; COWA: GPB, Grooved Pegboard
a
z-scores (mean of 0, SD of 1).
b
Percentage of patients with a z-score ≤ −2.0 for this test. Overall, 25/53 (47.2%) of patients were cognitively impaired per the OCFI.