. Author manuscript; available in PMC: 2014 Nov 15.

Published in final edited form as: Adv Drug Deliv Rev. 2013 Jul 13;65(0):10.1016/j.addr.2013.07.004. doi: 10.1016/j.addr.2013.07.004

Table 3. Organ-on-a-chip platforms for in vitro drug screening.

Organ/Tissue	Cultured Cell Type(s)	Replicated Organ Features and Functions	Refs
Liver	Hepatocytes, fibroblasts	Albumin and urea secretion, canalicular transport	[71-74]
Kidney	Inner medullary collecting duct (IMCD) cells	Molecular transport in response to hormonal stimulation	[75]
Lung	Alveolar basal epithelial, microvascular endothelial	Tight cell junctions, surfactant production, alveolar-capillary microarchitecture	[76-78]
Intestine	Gut epithelial	Villi formation, tight cell junctions, support of native flora	[79]
Heart	Cardiomyocytes	Synchronized contraction	[80]
Central nervous system	Neurons, oligodendrocytes	Physically separated axons and cell bodies, anisotropic axon growth	[81]