Skip to main content
. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Transl Res. 2013 Oct 1;162(6):10.1016/j.trsl.2013.09.003. doi: 10.1016/j.trsl.2013.09.003

Figure 1. Telomeres as targets in esophageal cancer.

Figure 1

(A) Shortening of telomeres (dashed lines) is prevented by telomerase. In Barrett’s esophageal adenocarcinoma cells homologous recombination (HR) and RAD51 also contribute to telomere stabilization71. (B) Inhibition of telomerase in these cells increases DNA breaks (DBS) as well as RAD51 expression and HR activity71 indicating that telomerase has a role in DNA repair. Telomerase inhibition leads to gradual telomere shortening and apoptosis. (C) Suppression of both telomerase and HR expedite telomere erosion and apoptosis in these cells71.