| Inhibition of Angiogenesis by TSP1 |
3,0E-06 |
NS |
CD47, JUN, GUCY1A3, CD36, AKT3, NOS3 |
JUN, CD36 |
| Corticotropin Releasing Hormone Signaling |
1,5E-05 |
NS |
JUN, GUCY1A3, BDNF, CRH, NR4A1, PTGS2, ADCY8, NOS3, NPR2 |
JUN, BDNF, UCN, CRH |
| cAMP-mediated Signaling |
2,0E-05 |
NS |
RGS2, CREM, CAMK2D, DUSP1, GRM3, PTH1R, S1PR1, P2RY12, HTR5B, STAT3, ADCY8, PDE1C |
CREM, GRM8, OPRK1, GABBR1, CHRM3 |
| RAR Activation |
3,4E-04 |
NS |
JUN, IL3RA, DUSP1, TGFB3, AKT3, ADCY8, SMAD1, CITED2, PPARGC1A |
JUN, IL3RA, SMAD1 |
| Acute Phase Response Signaling |
4,2E-04 |
NS |
FN1, JUN, ITIH4, IL6R, AKT3, CP, STAT3, CEBPB, TNFRSF11B |
JUN, C3, ITIH4, TNFRSF11B |
| Relaxin Signaling |
4,2E-04 |
NS |
JUN, GUCY1A3, RLN1, AKT3, ADCY8, NOS3, NPR2, PDE1C |
- |
| Synaptic Long Term Depression |
0,001 |
NS |
GUCY1A3, GRM3, PLA2G10, CRH, LYN, ADCY8, NOS3, NPR2 |
GRM8, CRH, LYN |
| ILK Signaling |
0,001 |
NS |
FN1, JUN, PPAP2B, AKT3, ACTG2 (includes EG:72), PTGS2, CCND1, IRS3, ITGB7 |
- |
|
IL-6 Signaling
|
0,001
|
0,008
|
ABCB1, JUN, IL6R, STAT3, CEBPB, TNFRSF11B
|
ABCB1, JUN, HSPB1, TNFRSF11B
|
| Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis |
0,002 |
NS |
FN1, JUN, WIF1, CAMK2D, LTA, CEBPD, IL6R, AKT3, STAT3, CEBPB, CCND1, TNFRSF11B |
JUN, TNFRSF11B, RYK |
| GM-CSF Signaling |
0,002 |
NS |
CAMK2D, LYN, AKT3, STAT3, CCND1 |
LYN |
|
PI3K Signaling in B Lymphocytes
|
0,002
|
0,005
|
JUN, CAMK2D, SYK, LYN, AKT3, VAV1, IRS3
|
JUN, C3, SYK, LYN, VAV1
|
| HIF1α Signaling |
0,003 |
NS |
JUN, SLC2A1, AKT3, MMP24, NOS3, SLC2A3 |
JUN, SLC2A3 |
| B Cell Receptor Signaling |
0,003 |
NS |
JUN, CAMK2D, SYK, EGR1, LYN, AKT3, VAV1 |
JUN, SYK, LYN, VAV1 |
| G-Protein Coupled Receptor Signaling |
0,003 |
NS |
RGS2, GRM3, GHRHR, HTR5B, STAT3, CELSR2, PDE1C, HCRTR2, CAMK2D, DUSP1, PTH1R, S1PR1, P2RY12, AKT3, ADCY8 |
GRM8, OPRK1, GABBR1, GPR88, CHRM3, CELSR2, HCRTR2 |
| LXR/RXR Activation |
0,003 |
NS |
APOC1, CD36, ACACA, PTGS2, TNFRSF11B |
APOC1, CD36, TNFRSF11B |
|
LPS/IL-1 Mediated Inhibition of RXR Function
|
0,005
|
0,001
|
APOC1, ABCB1, JUN, CYP2C9, ACOX2, ACSL6, SLCO1A2, TNFRSF11B
|
APOC1, ABCB1, CYP4A14, JUN, SLC10A1, SLCO1A2, TNFRSF11B
|
| TR/RXR Activation |
0,006 |
NS |
SLC2A1, AKT3, ACACA, THRSP, PPARGC1A |
THRB, THRSP |
| Glucocorticoid Receptor Signaling |
0,006 |
NS |
TSC22D3, JUN, HSPA1A, DUSP1, TGFB3, AKT3, STAT3, CEBPB, PTGS2 |
JUN, HSPA1A, ANXA1 |
|
Intrinsic Prothrombin Activation Pathway
|
0,007
|
0,002
|
KLK1, THBD, COL18A1
|
KLK1, THBD, COL18A1
|
| Crosstalk between Dendritic Cells and Natural Killer Cells |
0,007 |
NS |
CAMK2D, IL3RA, KLRD1, LTA, ACTG2 (includes EG:72) |
IL3RA, KLRD1 |
| Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes |
0,007 |
NS |
SYK, LYN, AKT3, VAV1, ACTG2 (includes EG:72) |
SYK, LYN, VAV1 |
| PPAR Signaling |
0,008 |
NS |
JUN, PTGS2, CITED2, TNFRSF11B, PPARGC1A |
JUN, TNFRSF11B |
| HGF Signaling |
0,010 |
NS |
JUN, AKT3, STAT3, PTGS2, CCND1 |
JUN |
|
Disease associated pathways
|
|
|
|
|
|
Huntington's Disease Signaling
|
0,001
|
0,003
|
TGM2, NSF, CAPN8, KLK1, JUN, BDNF, HSPA1A, SGK1, AKT3, GOSR2
|
TGM2, CAPN8, KLK1, JUN, BDNF, HSPA1A, GOSR2
|
| Colorectal Cancer Metastasis Signaling |
0,004 |
NS |
JUN, IL6R, TGFB3, AKT3, STAT3, MMP24, PTGS2, ADCY8, CCND1 |
- |
| Type II Diabetes Mellitus Signaling |
0,004 |
NS |
ACSL6, CD36, AKT3, CEBPB, IRS3, TNFRSF11B |
CD36, TNFRSF11B |
|
Hepatic Cholestasis
|
0,009
|
0,0001
|
SLCO1C1, ABCB1, JUN, SLCO1A2, ADCY8, TNFRSF11B
|
SLCO1C1, ABCB1, JUN, SLC10A1, ABCC1, SLCO1A2, TNFRSF11B
|
| Hepatic Fibrosis / Hepatic Stellate Cell Activation |
0,010 |
NS |
FN1, CTGF, LEPR, IL6R, TGFB3, TNFRSF11B |
LEPR, TGFA, TNFRSF11B |
