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. 2013 Nov 19;8(11):e81090. doi: 10.1371/journal.pone.0081090

Figure 8. Spironolactone partially normalizes bleomycin-induced alveolar macrophage alterations.

Figure 8

A shows the gating strategies for mouse pulmonary alveolar macrophages using lung lavage. B and C show the dynamic profiles of lung alveolar M1-like (F4/80+CD11c+CD206-) and M2-like (F4/80+CD11c+CD206+) macrophages in all treatment groups, respectively. Panel D shows the representative temporal profiles of flow cytometry analysis (pseudocolor plots) of lung alveolar macrophages in all treatment groups. Abbreviations: BLM, bleomycin; FSC, forward-scattered light; NS, normal saline; SP, spironolactone; SSC, side-scattered light. *P<0.05 vs. NS group. #P<0.05 vs. BLM and BLM + SP groups (n = 5 to 7).