Table I.
Correlation between clinicopathological factors and expression of miR-21 in serum.
| Clinicopathological factors | n | miR-21 expression (mean ± SD) | P-value |
|---|---|---|---|
| Gender | 0.504 | ||
| Male | 68 | −0.611±0.509 | |
| Female | 35 | −0.705±0.434 | |
| Age | 0.712 | ||
| ≤60 | 53 | −0.653±0.491 | |
| >60 | 50 | −0.631±0.483 | |
| Tumor size | 0.048a | ||
| ≤5 cm | 52 | −0.713±0.507 | |
| >5 cm | 51 | −0.571±0.455 | |
| Tumor thickness | 0.021a | ||
| pT1 | 18 | −0.798±0.507 | |
| pT2 + pT3 | 12 | −0.577±0.547 | |
| pT4a | 52 | −0.712±0.407 | |
| pT4b | 21 | −0.375±0.531 | |
| Nodal status | 0.376 | ||
| pN0 | 25 | −0.778±0.543 | |
| pN1 | 14 | −0.592±0.521 | |
| pN2 | 17 | −0.526±0.462 | |
| pN3 | 47 | −0.628±0.447 | |
| Distant metastasis | 0.196 | ||
| M0 | 89 | −0.667±0.491 | |
| M1 | 14 | −0.486±0.425 | |
| Venous invasion | 0.750 | ||
| Positive | 28 | −0.617±0.486 | |
| Negative | 75 | −0.652±0.485 | |
| Tumor differentiation | 0.443 | ||
| Poor | 59 | −0.611±0.452 | |
| Moderate/well | 44 | −0.685±0.528 | |
| UICC stage | 0.238 | ||
| I + II | 31 | −0.744±0.509 | |
| III | 58 | −0.626±0.481 | |
| IV | 14 | −0.486±0.425 | |
| Surgery type | 0.100 | ||
| Radical | 80 | −0.690±0.470 | |
| Palliative | 23 | −0.478±0.508 |
a
Indicates a significant difference (P<0.05).
Since the relative quantity (Qrel) was logarithmic, Qrel was transformed through logarithmic transformation into linear distribution for statistical convenience. The negative expression values indicated that miR-21 was expressed less than arbitrary samples. UICC, Union for International Cancer Control; SD, standard deviation.