Table II.

Univariate and multivariate Cox analysis of prognostic factors in patients with GC.

		Univariate			Multivariate
Factors	Categories	RR	RR (95% CI)	P-value	RR	RR (95% CI)	P-value
Gender	Male/female	0.763	0.429–1.335	0.356	-	-	-
Age	>60/≤60	0.975	0.557–1.708	0.975	-	-	-
Tumor size	≥5/<5	2.685	1.423–5.070	0.002a	0.995	0.471–2.10	0.989
Depth of invasion	T1 + T2/T3 + T4	5.960	2.140–16.60	0.001a	0.001	0.0001–9.40	0.941
Lymph node metastasis	Positive/negative	7.001	2.173–22.554	0.001a	2.066	0.306–13.92	0.456
Differentiation	Poor/moderate	1.686	0.936–3.039	0.082	-	-	-
Venous invasion	Positive/negative	1.562	0.859–2.842	0.144	-	-	-
TNM stage	I + II/IV	0.097	0.034–0.275	<0.0001a	0.143	0.047–0.435	0.001a
	III/IV	0.272	0.134–0.553	<0.0001a	0.401	0.177–0.905	0.028a
Surgery type	Palliative/radical	0.195	0.110–0.347	<0.0001a	0.458	0.232–0.904	0.024a
Serum miR-21 expression	High/low	0.873	0.498–1.530	0.873	-	-	-

^aIndicates a significant difference (P<0.05).

CI, confidence interval; GC, gastric cancer.