Table 1.
One-carbon nutrients intake and other characteristics of breast cancer cases, cases with (M) and without (UM) promoter methylation, WEB Study 1996–2001
| E-cadherin | p16 | RAR-β2 | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| M (n = 161)§ | UM (n = 742)§ | M (n = 208)§ | UM (n = 595)§ | M (n = 221)§ | UM (n = 582)§ | |
| Age, y † | 58.0 ± 11.8 | 57.4 ± 11.2 | 58.0 ± 11.2 | 57.4 ± 11.3 | 57.4 ± 11.3 | 57.6 ± 11.3 |
| Race/ ethnicity | ||||||
| White | 148 (91.9%) | 594 (92.5%) | 192 (92.3%) | 550 (92.4%) | 210 (95.0%) | 532 (91.4%) |
| Non-white | 13 (8.1%) | 48 (7.5%) | 16 (7.7%) | 45 (7.6%) | 11 (5.0%) | 50 (8.6%) |
| ER status | ||||||
| + | 114 (71.3%) | 446 (70.0%) | 136 (65.7%) | 424 (71.9%) | 163 (74.8%) | 397 (68.6%) |
| − | 46 (28.7%) | 191 (30%) | 71 (34.3%) | 166 (28.1%) | 55 (25.2%) | 182 (31.4%) |
| Alcohol consumption | ||||||
| Never | 20 (12.6%) | 110 (17.3%) | 46 (22.3%) | 84 (14.2%) | 41 (18.7%) | 89 (15.4%) |
| Ever | 139 (87.4%) | 527 (82.7%) | 160 (77.7%) | 506 (85.8%) a | 178 (81.3%) | 488 (84.6%) |
| Dietary intake | ||||||
| Folate intake (μg/day) † | 281.7 ± 178.4 | 280.7 ± 178.4 | 275.2 ± 143.2 | 282.9 ± 158.9 | 285.5 ± 175.0 | 279.2 ± 146.6 |
| Vitamin B2 (mg/day) † | 1.7 ± 1.2 | 1.6 ± 1.2 | 1.5 ± 1.2 | 1.7 ± 1.2 | 1.7 ± 1.2 | 1.6 ± 1.2 |
| Vitamin B6 (mg/day) † | 1.4 ± 1.0 | 1.4 ± 1.1 | 1.4 ± 1.0 | 1.5 ± 1.1 | 1.4 ± 1.0 | 1.4 ± 1.1 |
| Vitamin B12 (μg/day) † | 3.3 ± 2.2 | 3.3 ± 2.1 | 3.1 ± 2.1 | 3.3 ± 2.2 | 3.3 ± 2.1 | 3.3 ± 2.2 |
| Methionine (g/day) † | 1.2 ± 0.9 | 1.1 ± 0.8 | 1.1 ± 0.4 a | 1.2 ± 0.6 | 1.2 ± 0.7 | 1.2 ± 0.5 |
§
M – methylated; UM – unmethylated;
†
Mean ± SD;
a
Comparison of methylated to unmethylated cases p < 0.05.