Table 3.

Interactions between dietary intake of one-carbon nutrients and alcohol consumption and likelihood of promoter methylation of E-cadherin, p16 and RAR- β₂ in breast tumors: case-case comparison

			E-cadherin			p16,			RAR-β2
	M	U	OR (95% CI) 1	M	U	OR (95% CI) 1	M	U	OR (95% CI) 1
Folate/ alcohol intake a
High/ Low	28	149	1.0	48	129	1.0	51	126	1.0
High/ High	43	155	1.74 (1.00–3.01)	49	149	0.91 (0.56–1.47)	54	144	0.89 (0.56–1.43)
Low/ Low	39	174	1.31 (0.73–2.34)	59	154	0.77 (0.47–1.25)	61	152	1.05 (0.65–1.70)
Low/ High	51	164	2.05 (1.16–3.62)	52	163	0.69 (0.42–1.14)	55	160	0.90 (0.55–1.47)
p interaction			0.77			0.97			0.89
Vitamin B2/ alcohol intake b
High/ Low	38	147	1.0	42	138	1.0	57	123	1.0
High/ High	49	155	1.60 (0.96–2.69)	42	162	0.87 (0.53–1.43)	59	145	0.86 (0.55–1.35)
Low/ Low	34	176	0.86 (0.48–1.56)	65	145	1.21 (0.73–2.00)	55	155	0.77 (0.47–1.27)
Low/ High	45	164	1.43 (0.81–2.54)	59	150	1.12 (0.67–1.89)	50	159	0.68 (0.41–1.13)
p interaction			0.93			0.84			0.95
Vitamin B6/ alcohol intake c
High/ Low	30	145	1.0	45	130	1.0	52	123	1.0
High/ High	49	157	1.74 (1.03–2.95)	46	160	0.84 (0.51–1.36)	54	152	0.83 (0.52–1.61)
Low/ Low	37	178	1.01 (0.56–1.82)	62	153	0.88 (0.53–1.45)	60	155	1.00 (0.61–1.63)
Low/ High	45	162	1.56 (0.87–2.78)	55	152	0.85 (0.51–1.41)	55	152	0.92 (0.56–1.52)
p interaction			0.73			0.67			0.74
Vitamin B12/ alcohol intake d
High/ Low	29	155	1.0	49	135	1.0	53	131	1.0
High/ High	51	163	2.00 (1.18–3.42)	50	164	0.89 (0.55–1.43)	55	159	0.82 (0.52–1.31)
Low/ Low	38	168	1.35 (0.77–2.37)	58	148	0.92 (0.58–1.47)	59	147	1.03 (0.65–1.64)
Low/ High	43	156	1.85 (1.04–3.27)	51	148	0.84 (0.51–1.38)	54	145	0.96 (0.59–1.56)
p interaction			0.29			0.93			0.71
Methionine/ alcohol intake e
High/ Low	35	146	1.0	52	129	1.0	55	126	1.0
High/ High	57	167	1.65 (1.00–2.71)	49	175	0.71 (0.45–1.14)	61	163	0.84 (0.54–1.31)
Low/ Low	32	177	0.69 (0.39–1.24)	55	154	0.63 (0.38–1.03)	57	152	0.92 (0.57–1.50)
Low/ High	37	152	1.07 (0.60–1.92)	52	137	0.70 (0.42–1.18)	48	141	0.84 (0.50–1.40)
p interaction			0.87			0.17			0.81

¹Odds ratios and 95% confidence intervals adjusted for age, race, education, energy, menopausal status, age at menopause, and smoking status.

Cutoff point for lifetime total alcohol (oz): 697.18.

^aCutoff point for diet folate (mcg/day):252.32.

^bCutoff point for diet vitamin B₂ (mg/day):1.63.

^cCutoff point for diet vitamin B₆ (mg/day):1.46.

^dCutoff point for diet vitamin B₁₂ (mcg/day):3.32.

^eCutoff point for diet methionine (g/day):1.12.