Table 2.
Site | Pure estrogen | SERMs | Pure antiestrogen | |
---|---|---|---|---|
1st generation | 2nd generation | |||
Bone | Agonist | Agonist | Agonist | Antagonist |
Cholesterol | Agonist | Agonist | Agonist | - |
Uterus | Agonist | Partial agonist | Antagonist | Antagonist |
Mammary | Agonist | Antagonist | Antagonist | Antagonist |
Prototype | 17-estradiol | Tamoxifen | Raloxifene | ICI-164384 |