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The target of SERMs
| Site | Pure estrogen | SERMs | Pure antiestrogen | |
|---|---|---|---|---|
| 1st generation | 2nd generation | |||
| Bone | Agonist | Agonist | Agonist | Antagonist |
| Cholesterol | Agonist | Agonist | Agonist | - |
| Uterus | Agonist | Partial agonist | Antagonist | Antagonist |
| Mammary | Agonist | Antagonist | Antagonist | Antagonist |
| Prototype | 17-estradiol | Tamoxifen | Raloxifene | ICI-164384 |
