Table 4.
Necropsy findings after oral treatment of platycodin D
| Dose (mg/kg) | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 2000 | 1000 | 500 | 250 | 125 | 0 | 2000 | 1000 | 500 | 250 | 125 | |
| Lung | ||||||||||||
| Normal | 4/5 | 4/5 | 4/5 | 4/5 | 4/5 | 4/5 | 3/5 | 5/5 | 4/5 | 4/5 | 4/5 | 4/5 |
| Congestion | 1/5 | 1/5 | 1/5 | 1/5 | 1/5 | 1/5 | 2/5 | 0/5 | 1/5 | 1/5 | 1/5 | 1/5 |
| Thymus | ||||||||||||
| Normal | 4/5 | 5/5 | 4/5 | 3/5 | 3/5 | 4/5 | 4/5 | 5/5 | 3/5 | 3/5 | 3/5 | 4/5 |
| Atrophy | 1/5 | 0/5 | 1/5 | 2/5 | 2/5 | 1/5 | 1/5 | 0/5 | 2/5 | 2/5 | 2/5 | 1/5 |
| Kidney | ||||||||||||
| Normal | 5/5 | 5/5 | 5/5 | 5/5 | 4/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 4/5 | 5/5 |
| Cyst | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 | 0/5 |
| Spleen | ||||||||||||
| Normal | 3/5 | 4/5 | 3/5 | 4/5 | 3/5 | 4/5 | 2/5 | 4/5 | 3/5 | 4/5 | 3/5 | 5/5 |
| Atrophy | 2/5 | 1/5 | 2/5 | 1/5 | 2/5 | 0/5 | 2/5 | 1/5 | 2/5 | 1/5 | 2/5 | 0/5 |
| Hypertrophy | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 | 1/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
| LNa | ||||||||||||
| Normal | 3/5 | 4/5 | 1/5 | 4/5 | 4/5 | 5/5 | 2/5 | 1/5 | 5/5 | 3/5 | 3/5 | 5/5 |
| Hypertrophy | 2/5 | 1/5 | 3/5 | 1/5 | 1/5 | 0/5 | 3/5 | 4/5 | 0/5 | 2/5 | 2/5 | 0/5 |
| Focal hemorrhage | 0/5 | 0/5 | 1/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Observed animals/total observed animals (five mice).
aBilateral popliteal lymph node.