Table 4.
Hematological findings of female rats treated orally with G. bimaculatus for 13 weeks
| Item | Unit | CONa | 0.04 | 0.2 | 1 | 5 (g/kg bw/day) |
|---|---|---|---|---|---|---|
| WBC | 103/mm3 | 6.6 ± 2.3 | 6.3 ± 0.7 | 6.6 ± 2.0 | 5.4 ± 1.6 | 4.1 ± 0.3 |
| RBC | 106/mm3 | 9.0 ± 0.3 | 8.6 ± 0.4 | 8.2 ± 0.8* | 8.3 ± 0.7* | 7.8 ± 0.3* |
| Hgb | g/dl | 16.7 ± 0.6 | 16.2 ± 0.9 | 15.2 ± 2.0 | 15.7 ± 1.5 | 14.8 ± 0.5* |
| Hct | % | 53.4 ± 2.9 | 50.0 ± 3.7 | 48.9 ± 6.4 | 48.1 ± 5.2* | 49.8 ± 2.4* |
| MCV | fl | 59.3 ± 2.7 | 57.7 ± 1.6 | 58.9 ± 2.5 | 57.7 ± 1.6 | 63.3 ± 3.6 |
| MCH | pg | 18.5 ± 0.4 | 18.7 ± 0.4 | 18.4 ± 0.6 | 18.8 ± 0.5 | 18.7 ± 0.3 |
| MCHC | g/dl | 31.3 ± 1.1 | 32.4 ± 0.7* | 31.2 ± 0.9 | 32.6 ± 0.9* | 29.7 ± 1.8* |
| PLT | 103/mm3 | 774.7 ± 281.4 | 922.6 ± 215.8 | 812.3 ± 204.0* | 884.1 ± 253.4 | 850.7 ± 150.2* |
| PTT | sec | 86.1 ± 56.7 | 96.0 ± 17.9 | 118.0 ± 35.5 | 103.4 ± 25.1 | 105.5 ± 40.6 |
| Thrombin time | sec | 134.6 ± 58.0 | 155.0 ± 55.1 | 128.7 ± 56.2 | 122.8 ± 44.3 | 68.7 ± 6.0 |
| Factor I | mg/dl | 100.8 ± 34.6 | 95.4 ± 18.3* | 105.0 ± 29.3 | 97.7 ± 36.3 | 110.0 ± 41.2 |
| PT | sec | 2.8 ± 0.8 | 4.6 ± 3.4 | 3.1 ± 1.3 | 6.9 ± 4.4 | 2.5 ± 1.1 |
| Neutrophil | % | 14.1 ± 5.3 | 12.9 ± 5.3 | 8.2 ± 4.5* | 11.9 ± 5.4 | 10.9 ± 5.8 |
| Lymphocyte | % | 81.9 ± 5.9 | 83.0 ± 6.0* | 85.9 ± 6.2* | 82.0 ± 7.8 | 83.2 ± 4.8 |
| Monocyte | % | 1.6 ± 0.7 | 1.3 ± 0.6 | 2.3 ± 1.4 | 3.2 ± 3.7 | 2.8 ± 1.1 |
| Eosinophil | % | 1.7 ± 0.5 | 2.2 ± 0.8 | 2.0 ± 1.7 | 2.4 ± 1.5 | 1.8 ± 1.3 |
| Basophil | % | 0.4 ± 0.1 | 0.3 ± 0.1 | 1.4 ± 3.0 | 0.3 ± 0.10* | 1.0 ± 1.1 |
Abbreviations: WBC, white blood cell, RBC, red blood cell, Hgb, hemoglobin, Hct, hematocrit, MCV, mean corpuscular volume, MCH, mean corpuscular hemoglobin, MCHC, mean corpuscular hemoglobin concentration, PLT, platelet. PTT, partial thromboplastin time, PT, prothrombin time.
aCON :PBS (as a vehicle) treated with murine normal dieta
Each value represents mean±S.D. Statistically significant from control (*P <0.05)