Table 10.

Histopathological findings of organs in male rats treated orally with G. bimaculatus for 13 weeks

Histopathological findings	0 (CONa)				0.04				0.2				1				5 (g/kg bw/day)
	-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
Kidney
Chronic nephritis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Pyelonephritis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Microcalcification	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Nuclear enlargement (cellular atypia)	10	0	0	0	10	0	0	0	0	10	0	0	10	0	0	0	10	0	0	0
Liver
Vasculitis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Necrosis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Lung
Epithelioid granulomas	10	0	0	0	0	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Foamy cell collection	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Spleen
Hemosiderosis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Extramedullary hematopoiesis	10	0	0	0	0	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Testis
Necrosis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Stomach
Necrosis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Pancreas
Fat necrosis	0	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Thymus
Agonal hemorrhage	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0
Lymphocytic necrosis	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0	10	0	0	0

^aCON: treated with PBS buffer.

-: Normal, +: Mild, ++: Moderate, +++: Severe.

Values are number of animals presenting the histopathological lesions.

The value of 0 of animals means non-significant finding.