Table 2.
Acute toxicity of PAs
| Compound | Species | Route of administration | LD50 (mg/kg body weight | Ref. |
|---|---|---|---|---|
| PA (ortho-PA) | Mouse | i.p. | 550 | - |
| Mouse | Oral | 2530 | - | |
| Rat | N/R | 1100 | GISAAA, 1967 | |
| Rat | Oral | 7900 | - | |
| TPA (Tere-PA) | Mouse | Oral | > 5000 | Hoshi et al., 1968 |
| 6400 | Moffitt et al., 1975 | |||
| 1470 | Moffitt et al., 1975 | |||
| Rat | > 5000 | |||
| > 15380 | Amoco Co., 1990; | |||
| 1960 | Amoco Co., 1975; | |||
| 18800 | ||||
| Mouse | i.p. | 1430 | ||
| [1240-1650] | Hoshi et al., 1968 | |||
| 880 | Grigas et al., 1971 | |||
| 1900 | ||||
| Rat | 1210 | - | ||
| 2250 | ||||
| Mouse | i.v. | 770 | - | |
| Na2TPA | Mice | Oral | 6300(5000) | Hoshi et al., 1968 |
| [5600-7150] | ||||
| s.c. | 8600(6800) | |||
| [7760-9550] | ||||
| i.p. | 4600(3600) | |||
| [4260-4870] | ||||
| i.v. | 1300 or more | |||
| (1000 or more) | ||||
| IPA (Iso-PA) | Rat | Oral | > 5,000 | IITRI, 1990 |
| 13,000 | Industrial BIO-TEST, 1975 | |||
| 10,900 | Industrial BIO-TEST, 1975 | |||
| 12,200 | Industrial BIO-TEST, 1958 | |||
| 10,400 | Marhold, 1986 | |||
| Rat | Inhalation | LC50 | ||
| > 11.37 g/m3 | Industrial BIO-TEST, 1958 | |||
| Rabbit | Dermal | 2,000 | IITRI, 1990. | |
| 23,000 | Industrial BIO-TEST, 1958 | |||
| Rat | i.p. | 13,000 | Calandra, 1975 | |
| Mouse | 4200 | - | ||