Table 5.
Type | Species | Dose | Route/Period | Remarks | Ref. |
---|---|---|---|---|---|
Repeated dose | Rat | 0.5, 1.6, 5.0% (250, 800, 2,500 mg/kg/day) | Oral/13-week | - NOAEL: 250 mg/kg/day, | Vogin, 1972 |
- LOAEL: 800 mg/kg/day | |||||
*Slight increase in the incidence of crystalluria, mild hydronephrosis, and pelvic calcification | |||||
Rat | 1.0, 5.0, 10.0 mg/m3 | Inhalation/4-week (6 hours/day 5 days/week) | NOAEL > 10.0 mg/m3 | IITRI, 1988 |