Table 1.
[3H] PDBu binding following the exposure of substances (% of control)
| Non-ortho-substituted PCBs (μM) | 0.1 | 1 | 25 | 50 |
|---|---|---|---|---|
| 3,3',4,4',5-penta-CB (PCB-126) | 103 ± 09 | 110 ± 04 | 118 ± 12 | 126 ± 16 |
| 3,3',4,4',5,5'-hexa-CB (PCB-169) | 108 ± 08 | 105 ± 11 | 127 ± 21 | 121 ± 12 |
| Mono-ortho-substituted PCBs (μM) | 0.1 | 1 | 25 | 50 |
| 2,3,4,4',5-penta-CB (PCB-114) | 96 ± 11 | 105 ± 04 | 130 ± 18 | 145 ± 16* |
| 2,3,3',4,4',5-hexa-CB (PCB-157) | 92 ± 15 | 108 ± 18 | 135 ± 11* | 148 ± 13* |
| Non-dioxin-like PCBs (μM) | 0.1 | 1 | 25 | 50 |
| 2,2',5,5'-tetra-CB (PCB-52) | 102 ± 06 | 105 ± 12 | 155 ± 16* | 194 ± 11* |
| 2,2'-di-CB (PCB-4) | 105 ± 07 | 112 ± 05 | 168 ± 15* | 208 ± 18* |
The total activity of PKC was measured by [3H] phorbol ester binding assay in the presence of various concentrations (0, 0.1, 1, 25, 50 μM) of PCBs. All values are relative to the control cells treated with DMSO. Values represent the mean ± SD of three independent experiments. * p < 0.05 compared with the control.