Table 1.
Chemotherapy regimens and antiemetics received by patients in the study
| Type of regimen | Regimen protocol | Regimen details | Antiemetics prescribeda,b |
|---|---|---|---|
| Breast cancer regimens | AC | Intravenous Doxorubicin 60 mg/m2/day, Intravenous Cyclophosphamide 600mg/m2/day | Acute antiemetics: Intravenous Granisetron 3 mg, Intravenous Dexamethasone 8 mg Delayed antiemetics: Oral Granisetron 1 mg/day, Oral Dexamethasone 4 mg twice daily |
| FAC | Intravenous Doxorubicin 50 mg/m2/day, Intravenous Cyclophosphamide 500 mg/m2/day, Intravenous Fluorouracil 500 mg/m2/day | ||
| FEC (500/ 100/500) | Intravenous Epirubicin 100 mg/m2/day, Intravenous Cyclophosphamide 500 mg/m2/day, Intravenous Fluorouracil 500 mg/m2/day | ||
| FEC (500/ 75/500) | Intravenous Epirubicin 75 mg/m2/day, Intravenous Cyclophosphamide 500 mg/m2/day, Intravenous Fluorouracil 500 mg/m2/day | ||
| Gastro-intestinal cancers | XELOX | Intravenous Oxaliplatin 130 mg/m2/day, Oral Capecitabine 2000 mg/m2/day | Acute antiemetics: Intravenous Ondansetron 8 mg, Intravenous Dexamethasone 8mg Delayed antiemetics: Oral Ondansetron 8 mg/day, Oral Dexamethasone 4 mg twice daily |
| CDDP 40 | Intravenous Cisplatin 40 mg/m2/day | Acute antiemetics: Intravenous Granisetron 3 mg, Intravenous Dexamethasone 8 mg Delayed antiemetics: Oral Granisetron 1 mg/day, Oral Dexamethasone 4 mg twice daily | |
| Head and neck cancers | CDDP 100 | Intravenous Cisplatin 100 mg/m2/day | Acute antiemetics: Oral Aprepitant 125 mg, Intravenous Granisetron 3 mg, Intravenous Dexamethasone 8 mg Delayed antiemetics: Oral Aprepitant 80 mg/day (days 2~3), Oral Dexamethasone 4 mg twice daily |
| PF (80/1000) | Intravenous Cisplatin 20 mg/m2/day, Intravenous Fluorouracil 1000 mg/m2/day, for 4 days | Acute antiemetics: Intravenous Granisetron 3 mg (days 1~4), Intravenous Dexamethasone 8 mg (days 1~4) Delayed antiemetics: Oral Dexamethasone 4 mg twice daily (days 5~9) | |
aAcute antiemetics were given on the day of chemotherapy (day 1), while delayed antiemetics were given on days 2~4, unless stated otherwise.
bOral metoclopramide 20mg was prescribed up to 4 times daily when needed as rescue therapy.