Table 3.

Relative organ weights of animals exposed with prebrewed AS in the single dose toxicity study

Groups	Male vehicle control	Prebrewed AS treated male rats (mg/kg)			Female vehicle control	Prebrewed AS treated female rats (mg/kg)
		2,000	1,000	500		2,000	1,000	500
Organ weights (% of body weight)
Lung	0.42 ± 0.02	0.42 ± 0.02	0.42 ± 0.02	0.40 ± 0.02	0.51 ± 0.02	0.52 ± 0.02	0.52 ± 0.02	0.52 ± 0.02
Heart	0.31 ± 0.02	0.32 ± 0.01	0.32 ± 0.01	0.31 ± 0.01	0.36 ± 0.02	0.36 ± 0.02	0.36 ± 0.02	0.35 ± 0.02
Thymus	0.18 ± 0.02	0.18 ± 0.02	0.17 ± 0.03	0.16 ± 0.02	0.21 ± 0.02	0.23 ± 0.03	0.24 ± 0.01	0.23 ± 0.02
Kidney (left)	0.32 ± 0.02	0.32 ± 0.01	0.31 ± 0.01	0.30 ± 0.01	0.34 ± 0.02	0.33 ± 0.03	0.33 ± 0.03	0.32 ± 0.02
Adrenal gland (left)	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.01 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.02 ± 0.01
Spleen	0.20 ± 0.01	0.19 ± 0.01	0.21 ± 0.02	0.21 ± 0.01	0.21 ± 0.02	0.20 ± 0.01	0.22 ± 0.02	0.22 ± 0.02
Testis/Ovary (left)	0.54 ± 0.02	0.53 ± 0.01	0.53 ± 0.02	0.52 ± 0.04	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01
Liver	2.94 ± 0.09	2.92 ± 0.12	2.91 ± 0.08	2.92 ± 0.14	2.86 ± 0.08	2.87 ± 0.14	2.87 ± 0.11	2.80 ± 0.10
Brain	0.64 ± 0.02	0.63 ± 0.02	0.63 ± 0.02	0.65 ± 0.03	0.96 ± 0.05	0.98 ± 0.07	0.99 ± 0.04	0.95 ± 0.05
Lymph node (left)a)	0.19 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.03 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.03 ± 0.01
Epididymis (left)	0.12 ± 0.01	0.12 ± 0.02	0.14 ± 0.02	0.12 ± 0.01
Pancreas	0.21 ± 0.01	0.21 ± 0.03	0.21 ± 0.03	0.20 ± 0.03	0.24 ± 0.02	0.22 ± 0.02	0.24 ± 0.02	0.23 ± 0.01
Urinary bladder	0.32 ± 0.01	0.03 ± 0.01	0.03 ± 0.01	0.03 ± 0.01	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01
Prostate/Uterus	0.12 ± 0.02	0.14 ± 0.03	0.12 ± 0.02	0.13 ± 0.02	0.18 ± 0.05	0.22 ± 0.06	0.17 ± 0.02	0.21 ± 0.09

Values are expressed as mean ± S.D. of five rats except for 2,000mg/kg treated rats, which were four rats.

AS = Armeniacae Semen aqueous extracts.

^a)Submandibular lymph node.