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. 2010 Mar;26(1):1–8. doi: 10.5487/TR.2010.26.1.001

Table 1.

Frequently applied transgenic and knockout animals used in the field of toxicology

Knockout genes Type of animals Effects on toxicology References

Nrf2 C57BL/6 mice - increased hepatotoxicity to acetaminophen Reisman et al., 2009a, b; Tanaka et al., 2009; Reisman et al., 2009c; Maher et al., 2008
- decreased biliary excretion of sulfobromophthalein
- decreased bile acid accumulation
- decreased expression of detoxification enzymes and transporters
PPARα C57BL/6 mice - decreased expression of multidrug resistance-associated protein transporters Maher et al., 2008; Cheng and Klaassen, 2008a, b; Faiola et al., 2008
- abrogated downregulation of Oatp1a1, 1a4, 1b2, and Ntcp and induction of Cyp4A14 by perfluorodecanoic acid
- decreased PPAR-δ agonist-induced skeletal muscle damage and liver injury
FXR C57BL/6 mice - enhanced susceptibility of mice to alpha-naphthyl isothiocyanate-induced liver injury Cui et al., 2009; Cheng and Klaassen, 2008a, b
CAR C57BL/6 mice - abrogated induction of Cyp2B10 by perfluorodecanoic acid Phillips and Goodman, 2009; Cheng and Klaassen, 2008a, b
PXR C57BL/6 mice - no effect on alpha-naphthyl isothiocyanate- or perfluorocarboxylic acids-induced liver injury Cui et al., 2009; Cheng and Klaassen, 2008b