Table 4.
Four genes were found with link to HIV-1 in the CCR5-delta32 heterozygous group
| Significant higher Expression in CCR5-delta32 samples | ||||
|---|---|---|---|---|
| Gene |
Function (link to HIV-1) |
Beneficial effect for CCR5-delta32 carriers |
Reference |
|
| Transm. |
Repli. |
|||
| U2AF65 |
Splicing factor (enhances with the polypyrimidine tract of the splicosome of several HIV-1 genes) |
Unknown |
[35] |
|
| CD30L |
Regulation immune response (elevated CD30 levels during acute HIV-1 infection) |
Unknown |
[36] |
|
| PRKACB |
Catalytic subunit of camp-dependent protein kinase (coexpression with the HDF GliPR) |
Unknown |
[37] |
|
| TAP | Antigen presentation (HIV-1 abrogates TAP mediated peptide transport to MHC I presentation) | Possible | [38] | |
Only for TAP there was a beneficial effect pre-described in terms of viral transmission. For the other three genes there are currently no data concerning a beneficial effect available. (transm. = transmission, repli. = replication).