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. 2013 Nov 14;7:215. doi: 10.3389/fncel.2013.00215

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Copyright © 2013 Rokic and Stojilkovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NMDG⁺ permeability of rP2X2aR, rP2X2bR and rP2X4R expressed in HEK293 cells. (A–C) Patterns of ATP-induced currents in cells bathed in a normal physiological medium. Traces shown were obtained during the first (P2X4R) and third (P2X2aR and P2X2bR) ATP application. Black lines indicate exponential fittings, with τ_des shown below the traces. (D–I). Patterns of ATP-induced current (D–F) and reversal potential (G–I) in cells that have been continuously bathed in a medium containing only NMDG⁺. (D, inset) Temporal correlation between P2X2aR current (red trace) and reversal potential (blue circles). Note the lack of inward current (F) and the positive shift in reversal potential (I) in cells expressing P2X4R. Derived from Khadra et al. (2012).