Table 1.

Internal manifestations of scleromyxedema

Type of involvement	Manifestation
Muscular	Proximal myopathy, joint contractures, muscle weakness
Neurological	Encephalopathy, peripheral neuropathy, coma
Rheumatological	Joint pain, migrating arthritis, sclerodactyly, seronegative polyarthritis, carpal tunnel syndrome
Pulmonary	Obstructive/restrictive lung disease, pulmonary hypertension
Renal	Renal insufficiency
Cardiovascular	Myocardial infarction, hypertension, atherosclerosis
Ophthalmological	Corneal deposits, thinning of the eyelid, ectropion