Table 2.

Treatment modalities of scleromyxedema

Treatment modality	References
Systemic corticosteroids	[10]
Cyclophosphamide	[11, 12]
Melphalan	[15]
Interferon α	[16]
Cyclosporine A	[17, 18]
Plasmapheresis	[19, 20]
Methotrexate	[21]
Chlorambucil joined with PUVA	[22]
Surgical intervention	[23]
2-chlordeoxyadenosine	[24]
Retinoids	[25]
Mucopolysaccharides (thiomucase)	[26]
Thalidomide	[7, 14]
Immunoglobulins	[6, 27–30]
Autologous stem cell transplantation	[13, 31, 32]
Biological treatment – bortezomib	[13, 14]