Table 3.
Human nuclear receptors and their active ligands
| Receptor | Ligand |
|---|---|
| All-trans retinoic acid receptor α (RARα) All-trans retinoic acid receptor β (RARβ) All-trans retinoic acid receptor γ (RARγ) |
All-trans retinoic acid, 9-cis retinoic acid, retinoids All-trans retinoic acid, 9-cis retinoic acid, retinoids All-trans retinoic acid, 9-cis retinoic acid, retinoids |
| 9-cis retinoic acid receptor α (RXRα) 9-cis retinoic acid receptor β (RXRβ) 9-cis retinoic acid receptor γ (RXRγ) |
9-cis retinoic acid, rexinoids 9-cis retinoic acid, rexinoids 9-cis retinoic acid, rexinoids |
| Thyroid hormone receptor α (TRα) Thyroid hormone receptor β (TRβ) |
Thyroid hormone Thyroid hormone |
| Vitamin D3 receptor (VDR) | Calcitriol |
| Peroxisome proliferator-activated receptor α (PPARα) Peroxisome proliferator-activated receptor β (PPARβ) Peroxisome proliferator-activated receptor γ (PPARγ) |
Fatty acids, fibrates, leukotriene B4
Fatty acids Fatty acids, thiazolidinediones |
| Pregnane X receptor (PXR) | Xenobiotics |
| Liver X receptor α (LXRα) Liver X receptor β (LXRβ) |
Oxysterols Oxysterols |
| Estrogen receptor α (ERα) Estrogen receptor β (ERβ) |
Estradiol-17, tamoxifen Estradiol-17 |
| Progesterone receptor (PR) | Progesterone, RU 486 |
| Glucocorticoid receptor (GR) | Cortisol, dexamethasone, RU 486 |
| Mineralocorticoid receptor (MR) | Aldosterone, spironolactone |
| Androgen receptor (AR) | Testosterone, flutamide |