Table 3.

Treatment of primary, secondary and early latent syphilis

Drug	Dose, administration	Treatment duration	Level of evidence
Benzathine penicillin	2.4 million units, IM	Single dose	Ib
Procaine penicillin	600 000 units once daily, IM	10–14 days	IIb
Alternatives
Doxycycline	200 mg once daily, PO	14 days	III
Tetracycline	500 mg 4× daily, PO	14 days	III
Erythromycin	500 mg 4× daily, PO	14 days	IV
Azithromycin*	2 g, PO	Single dose	Ib
Ceftriaxone*	500 mg once daily, IM	10 days	Ib

^*See the text