Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Treatment of neurosyphilis
| Drug | Dose, administration | Treatment duration | Level of evidence |
|---|---|---|---|
| Crystalline penicillin | 12–24 million units daily, 3–4 million units every 4 h, I.V. |
18–21 days (IUSTI) 10–14 days (CDC) |
III |
| Procaine penicillin | 1.2–2.4 million units once daily, IM, plus probenecid 500 mg 4× daily, PO |
10–17 days (IUSTI) 10–14 days (CDC) |
IIb |
| Alternatives | |||
| Doxycycline | 200 mg 2× daily, PO | 28 days | IV |
