Table 1.

General guidelines to manage acneiform rash associated with erlotinib [7, 13]

Severity	Erlotinib	Treatment	Continuation
Mild	Continuation of drug administration at a given dose	Topically hydrocortisone 1% or 2.5% cream and/or clindamycin 1% gel	Re-evaluation within 2 weeks, if no improvement – treat as the mild grade
Moderate	Continuation of drug administration at a given dose	Hydrocortisone 2.5% cream or clindamycin 1% gel or pimecro limus 1% cream and doxycycline 100 mg 2 times daily or minocycline 100 mg 2 times daily	Re-evaluation within 2 weeks, if no improvement – treat as the severe grade
Severe	Decrease the erlotinib dose and lesion monitoring	Treat as above in case of moderate grade and adding methylprednisolone can be considered	Re-evaluation within 2 weeks and if worse discontinuation of therapy should be considered