Table 1.
Severity | Erlotinib | Treatment | Continuation |
---|---|---|---|
Mild | Continuation of drug administration at a given dose | Topically hydrocortisone 1% or 2.5% cream and/or clindamycin 1% gel | Re-evaluation within 2 weeks, if no improvement – treat as the mild grade |
Moderate | Continuation of drug administration at a given dose | Hydrocortisone 2.5% cream or clindamycin 1% gel or pimecro limus 1% cream and doxycycline 100 mg 2 times daily or minocycline 100 mg 2 times daily | Re-evaluation within 2 weeks, if no improvement – treat as the severe grade |
Severe | Decrease the erlotinib dose and lesion monitoring | Treat as above in case of moderate grade and adding methylprednisolone can be considered | Re-evaluation within 2 weeks and if worse discontinuation of therapy should be considered |