Table 1.
Average coronary flow and end-diastolic pressures at the end of perfusion in the isolated perfused rat hearts
| Type of perfusion | ||||||||
|---|---|---|---|---|---|---|---|---|
| Aerobic | I/R (20/30) | |||||||
| Compound | – | – | ML-7 | Y-27632 | Doxy | |||
| Concentration (μM) | – | – | 1 | 5 | 0.05 | 1 | 1 | 30 |
| n | 9 | 9 | 7 | 9 | 7 | 6 | 9 | 9 |
| Coronary flow (mL·min−1) | 17.30 | 6.267* | 4.029* | 15.44# | 6.671* | 14.83# | 6.111* | 15.18# |
| SEM | ± 0.5548 | ± 1.452 | ± 1.587 | ± 0.8577 | ± 2.149 | ± 0.5578 | ± 1.404 | ± 1.033 |
| End-diastolic pressure (mmHg) | 12.11 | 41.67* | 28.44* | 11.00# | 28.78 | 21.44*,# | 33.33* | 22.33*,# |
| SEM | ± 0.5386 | ± 6.205 | ± 4.451 | ± 0.7638 | ± 5.449 | ± 1.634 | ± 3.329 | ± 2.421 |
| Compound | Y-27632 + ML-7 | Y-27632 + Doxy | ML-7 + Doxy | Y-27632 + ML-7 + Doxy | ||||
| Concentration (μM) | 0.05 + 1 | 0.05 + 1 | 1 + 1 | 0.05 + 1 + 1 | ||||
| N | 9 | 9 | 9 | 9 | ||||
| Coronary flow (mL·min−1) | 9.667* | 10.67* | 10.99* | 15.69# | ||||
| SEM | ± 1.936 | ± 1.785 | ± 1.787 | ± 0.3638 | ||||
| End-diastolic pressure (mmHg) | 18.89*,# | 35.33* | 31.11* | 15.89# | ||||
| SEM | ± 1.720 | ± 6.526 | ± 4.931 | ± 2.150 | ||||
*
P < 0.05 versus aerobic;
#
P < 0.05 versus I/R.