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. 2013 Aug 27;170(2):440–457. doi: 10.1111/bph.12285

Figure 4.

Figure 4

Detection of flavonol glycosides and their metabolites in plasma (pink plots), bile (light green plots), and urine (gray plots) after a 15 min i.v. infusion dose of ShuXueNing injection (4 mL·kg−1) or a p.o. dose of GBE50 (90 mg·kg−1) in rats. The names of the flavonol glycosides 10–13, 19–22, 27, 29 and 30 and of the flavonol aglycones 16, 26 and 32, are given in Table 1. The conjugated metabolites M16G-1–M16G-4, M16S-1–M16S-3, M16G-S, M162S, M26G-1–M26G-3, M21/22S-3, M32G-1–M32G-3 and M32S-1/M32S-2 were quercetin glucuronide, quercetin sulfate, glucuronidated quercetin sulfate, quercetin disulfate, kaempferol glucuronide, kaempferol 3-O-rhamnosyl-O-glucoside/kaempferol 3-O-glucosyl-O-rhamnoside sulfate, isorhamnetin glucuronide and isorhamnetin sulfate respectively. M16G-1 and M26G-1 are quercetin-3-O-glucuronide and kaempferol-3-O-glucuronide respectively. The symbol ‘×’ (in red) indicates that no substance was detected in the sample. The symbol ‘?’ (in red) indicates that the substance was only detected once.