Table 2.

Plasma PK parameters of total flavonols and terpene lactones after an i.v. infusion dose of ShuXueNing injection in rats

PK parameter	t-Quercetin	t-Kaempferol	t-Isorhamnetin	Ginkgolide A	Ginkgolide B	Ginkgolide C	Ginkgolide J
ShuXueNing injection (15 min i.v. infusion at 1 mL·kg−1)
C15min (nM)	732 ± 107	1022 ± 186	163 ± 23	161 ± 25	64.5 ± 6.6	223 ± 29	68.4 ± 6.5
AUC0-t (h·nM)	687 ± 125	1116 ± 192	379 ± 57	72.8 ± 10.9	31.7 ± 4.6	114 ± 11	28.1 ± 4.4
MRT (h)	14.3 ± 4.4	15.0 ± 9.8	22.3 ± 5.2	0.46 ± 0.20	0.63 ± 0.08	0.67 ± 0.09	0.23 ± 0.05
t1/2-(1) (h)	1.86 ± 0.19	1.34 ± 0.11	2.91 ± 0.46	0.62 ± 0.21	0.77 ± 0.06	0.92 ± 0.07	0.31 ± 0.04
t1/2-(2) (h)	14.3 ± 3.8	21.5 ± 19.7	18.5 ± 4.2	N.A.	N.A.	N.A.	N.A.
CLtot,p (L·h−1·kg−1)	0.46 ± 0.08	0.45 ± 0.24	0.23 ± 0.04	3.85 ± 0.61	2.96 ± 0.42	1.63 ± 0.13	3.40 ± 0.54
VSS (L·kg−1)	6.55 ± 1.68	8.42 ± 3.75	4.99 ± 1.20	2.20 ± 0.72	2.22 ± 0.27	1.30 ± 0.17	1.19 ± 0.15
ShuXueNing injection (15 min i.v. infusion at 2 mL·kg−1)
C15min (nM)	1326 ± 275	1785 ± 420	293 ± 73	331 ± 28	120 ± 16	438 ± 72	154 ± 25
AUC0-t (h·nM)	1660 ± 266	2400 ± 401	927 ± 77	185 ± 17	72.5 ± 7.4	298 ± 16	87.3 ± 11.1
MRT (h)	23.9 ± 11.0	32.6 ± 4.0	25.4 ± 4.0	0.54 ± 0.04	0.62 ± 0.01	0.71 ± 0.10	0.41 ± 0.03
t1/2-(1) (h)	1.62 ± 0.19	1.86 ± 0.31	2.88 ± 0.45	0.73 ± 0.05	0.69 ± 0.01	0.88 ± 0.07	0.47 ± 0.09
t1/2-(2) (h)	20.8 ± 10.3	27.4 ± 4.2	18.0 ± 2.6	N.A.	N.A.	N.A.	N.A.
CLtot,p (L·h−1·kg−1)	0.32 ± 0.08	0.31 ± 0.08	0.29 ± 0.02	3.05 ± 0.20	2.68 ± 0.10	1.21 ± 0.08	2.09 ± 0.33
VSS (L·kg−1)	7.33 ± 2.04	10.1 ± 1.4	2.78 ± 0.21	2.01 ± 0.03	2.00 ± 0.09	1.01 ± 0.15	1.11 ± 0.12
ShuXueNing injection (15 min i.v. infusion at 4 mL·kg−1)
C15min (nM)	3607 ± 426	5113 ± 589	881 ± 86	884 ± 11	330 ± 8	1159 ± 40	407 ± 27
AUC0-t (h·nM)	3274 ± 482	6275 ± 330	2087 ± 240	429 ± 38	174 ± 20	622 ± 106	211 ± 19
MRT (h)	10.5 ± 4.2	34.7 ± 17.3	19.3 ± 4.6	0.57 ± 0.09	0.60 ± 0.08	0.54 ± 0.03	0.56 ± 0.06
t1/2-(1) (h)	1.91 ± 0.26	1.80 ± 0.13	3.13 ± 0.60	0.77 ± 0.09	0.66 ± 0.05	0.78 ± 0.07	0.69 ± 0.03
t1/2-(2) (h)	11.6 ± 3.3	30.2 ± 14.6	16.2 ± 3.7	N.A.	N.A.	N.A.	N.A.
CLtot,p (L·h−1·kg−1)	0.44 ± 0.13	0.25 ± 0.08	0.19 ± 0.04	2.75 ± 0.17	2.32 ± 0.19	1.24 ± 0.17	1.78 ± 0.12
VSS (L·kg−1)	4.26 ± 0.75	7.84 ± 2.73	3.56 ± 0.44	1.92 ± 0.30	1.68 ± 0.28	0.83 ± 0.07	1.22 ± 0.11

Because of its low content level in ShuXueNing injection (Table 1), a 15 min i.v. infusion dose of bilobalide at 1 mg·kg⁻¹ was given to FAC rats to obtain the plasma PK parameters of the compound. The C_15min, AUC_0-t, MRT, t_1/2, CL_tot,p, and V_SS value of bilobalide were 2696 ± 154 nM, 1619 ± 35 h·nM, 0.80 ± 0.05 h, 0.87 ± 0.06 h, 1.89 ± 0.04 L·h⁻¹·kg⁻¹ and 1.51 ± 0.11 L·kg⁻¹ respectively.