Table 3.
Summary of results from dose proportionality assessment
| Compound | r | P | Slope (90% CI) | Conclusion |
|---|---|---|---|---|
| AUC0-24h for the total flavonols and AUC0-6h for the terpene lactones | ||||
| Dose range of ShuXueNing injection (15 min i.v. infusion), 1–4 mL·kg−1 | ||||
| t-Quercetin | 0.976 | 3.04 × 10−7 | 1.105 (0.954–1.257) | Inconclusive |
| t-Kaempferol | 0.981 | 9.60 × 10−8 | 1.232 (1.084–1.380) | Inconclusive |
| t-Isorhamnetin | 0.987 | 1.81 × 10−8 | 1.167 (1.051–1.282) | Inconclusive |
| Ginkgolide A | 0.990 | 4.97 × 10−9 | 1.236 (1.130–1.341) | Inconclusive |
| Ginkgolide B | 0.984 | 1.14 × 10−9 | 1.171 (1.086–1.256) | Inconclusive |
| Ginkgolide C | 0.988 | 1.09 × 10−8 | 1.201 (1.089–1.314) | Inconclusive |
| Ginkgolide J | 0.986 | 2.24 × 10−8 | 1.450 (1.302–1.597) | Nonlinear |
| AUC0-24h for the total flavonols and AUC0-8h for the terpene lactones | ||||
| Dose range of GBE50 (p.o.), 10–90 mg·kg−1 | ||||
| t-Quercetin | 0.973 | 4.64 × 10−7 | 1.668 (1.428–1.908) | Nonlinear |
| t-Kaempferol | 0.985 | 1.96 × 10−7 | 1.153 (1.022–1.284) | Inconclusive |
| t-Isorhamnetin | 0.988 | 1.48 × 10−8 | 1.582 (1.429–1.735) | Nonlinear |
| Bilobalide | 0.988 | 1.14 × 10−12 | 0.978 (0.945–1.011) | Linear |
| Ginkgolide A | 0.990 | 6.52 × 10−9 | 1.028 (0.938–1.119) | Inconclusive |
| Ginkgolide B | 0.986 | 2.58 × 10−8 | 1.037 (0.930–1.144) | Inconclusive |
| Ginkgolide C | 0.973 | 5.04 × 10−7 | 0.796 (0.680–0.911) | Inconclusive |
| Ginkgolide J | 0.974 | 4.11 × 10−7 | 1.376 (1.181–1.572) | Nonlinear |
Critical intervals were 0.839–1.161 for the plasma data with ShuXueNing injection and 0.898–1.102 for those with GBE50. The term ‘r’ denotes the correlation coefficient. Correlations were statistically significant with a ‘P’ value of <0.05. The term ‘linear’ was concluded if the 90% confidence interval (90% CI) for slope was contained completely within the critical interval; ‘inconclusive’ was concluded if the 90% CI lay partly within the critical interval; ‘nonlinear’ was concluded if the 90% CI was entirely outside the critical interval.